The ISNT rule and differentiation of normal from glaucomatous eyes.
نویسندگان
چکیده
OBJECTIVE To determine whether the ISNT rule (that normal eyes show a characteristic configuration for disc rim thickness of inferior > or = superior > or = nasal > or = temporal), widely used for clinical evaluation of the optic nerve head, can differentiate normal from glaucomatous eyes. METHODS All subjects underwent complete eye examination, including achromatic automated perimetry, simultaneous stereoscopic disc photography, and confocal scanning laser ophthalmoscopy. Subjects with normal eyes had no evidence of glaucoma or ocular hypertension and had normal perimetry measurements. Subjects with glaucoma had a reproducible visual field defect. One eye from each subject was randomly enrolled. The ISNT rule was assessed by masked evaluation of disc photographs at the 3, 6, 9, and 12 o'clock positions. RESULTS Sixty-six subjects with normal eyes (33 black and 33 white individuals) and 43 with open-angle glaucoma (15 black and 28 white individuals) were enrolled. The ISNT rule was intact in 52 (79%) of 66 normal eyes and 12 (28%) of 43 glaucomatous eyes (P<.001). Multiple logistic regression indicated that the odds ratio for glaucoma associated with violation of the ISNT rule was 6.04 (95% confidence interval, 1.74-20.95) after adjustment for age; race was not a confounder of this association. CONCLUSION The ISNT rule is useful in differentiating normal from glaucomatous optic nerves and is unaffected by race.
منابع مشابه
Factors Affecting ISNT Rule Satisfaction in Normal and Glaucomatous Eyes
PURPOSE To determine the factors that influence the satisfaction of the 'ISNT rule' (neural rim width: inferior ≥ superior ≥ nasal ≥ temporal) in normal and glaucomatous eyes. METHODS The medical records of patients that visited Boramae Medical Center, Seoul, Korea, were reviewed. Each group of normal and glaucomatous eyes was divided into subgroups based on whether or not they satisfied the ...
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REFERENCES AND LINKS [1] N. Patton, T. M. Aslam, T. MacGillivray, I. J. Deary, B. Dhillon, R. H. Eikelboom, K. Yogesana, I. J. Constable, “Retinal image analysis: Concepts, applications and potential”, Prog. Retin. Eye Res. 25, 99–127 (2006). [2] N. Harizman, C. Oliveira, A. Chiang, C. Tello, M. Marmor, R. Ritch, J.M. Liebmann, “The ISNT rule and differentiation of normal from glaucomatous eyes...
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عنوان ژورنال:
- Archives of ophthalmology
دوره 124 11 شماره
صفحات -
تاریخ انتشار 2006